A comprehensive review on communication method in bacteria
DOI:
https://doi.org/10.14719/tcb.7812Keywords:
Gram-negative bacteria, Gram- positive bacteria, signalling, QSAbstract
Quorum Sensing (QS) represents a pivotal mechanism by which bacteria regulate gene expression in response to population density via the production and detection of small signaling molecules known as autoinducers. Numerous bacterial characteristics that are essential to their survival and pathogenicity, such as bioluminescence, biofilm formation, virulence factor expression, antibiotic resistance and environmental adaption, are regulated by this intercellular communication. Gram-positive bacteria use oligopeptides as autoinducers, while Gram-negative bacteria usually use N-acyl homoserine lactones (AHLs). In addition to aiding microbial pathogenicity, the QS system is crucial for bioremediation, plant-microbe interactions that increase agricultural output, tailored drug delivery in nanomedicine and global biogeochemical cycling that controls nutrient turnover. Research on QS as a potential target for antimicrobial therapeutics has increased in response to the escalating Antimicrobial Resistance (AMR) challenge. The ability of QS Inhibitors (QSIs) and Quorum Quenching (QQ) enzymes to interfere with bacterial communication and reduce virulence without applying selection pressure that increases resistance is being studied. Both synthetic and natural QSIs, as well as delivery techniques based on nanotechnology, have demonstrated promise in the fight against infections that are resistant to several drugs. Furthermore, using QS circuits in biotechnology opens up possibilities for improving the manufacture of medicinal biomolecules and biofuel. Ultimately, QS is a key area of focus for expanding our knowledge of microbial ecology and creating sustainable solutions for business, agriculture and medicine. Future research directed towards unraveling QS complexities and refining QQ strategies holds the potential to revolutionize microbial management and therapeutic interventions.
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